Dimethyl Sulfoxide
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide ACS reagent, >=99.9% | 67-68-5 | MFCD00002089 | 500ML
Dimethyl sulfoxide ACS reagent, >=99.9% | Purity: >=99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500ML
Supelco Inc Dimethyl Sulfoxide Biotech, 50 Milliliter
Dimethyl sulfoxide; 50mL; M.W. 78.13; (CH3)2SO; B.P. 189 deg.C(lit.); M.P. 16 deg. to 19 deg.C(lit.); CAS: 67-68-5
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 1L
Molecular Formula: (CH3)2SO, Molecular Weight: 78.13, Beilstein Registry Number: 506008, Assay: ≥99.5% (GC)
Crescent Chemical Co Inc DIMETHYL SULFOXIDE
Dimethyl sulfoxide research grade Highly active solvent and pharmaceutical vehicle; for freezing cells. For gradient centrifugation (1). Determination of cysteine and cystine in proteins (2). Size - 250ML Storage Conditions - +15 °C TO +30 °C Catalog
Apexbio Technology LLC MC1568 852475-26-4 10mM (in 1mL DMSO)
MC1568 (CAS 852475-26-4) is a histone deacetylase (HDAC) inhibitor derived from the (aryloxopropenyl)pyrrolyl hydroxyamide chemical class It selectively targets class II HDAC enzymes particularly class IIa subtypes (HDAC4 HDAC5 HDAC7 HDAC9) inhibiting maize class II HDAC activity with an IC50 of 22 M MC1568 modulates muscle differentiation pathways by reducing MEF2D expression stabilizing HDAC-HDAC3-MEF2D complexes and preventing MEF2D acetylation in cultured myocytes It also interferes with differentiation signals mediated via RAR and PPAR nuclear receptors serving as a valuable tool in epigenetic and cellular differentiation studies
Medchemexpress LLC Cwi1-2 10 Mm - 1 Ml In Dmso | HY-153274-10MM-1ML DMSO
Cwi1-2 10 Mm - 1 Ml In Dmso
Apexbio Technology LLC Apremilast (CC-10004) 608141-41-9 10mM (in 1mL DMSO)
Apremilast (CC-10004 CAS 608141-41-9) is a small-molecule inhibitor of phosphodiesterase 4 (PDE4) an enzyme involved in cyclic adenosine monophosphate (cAMP) hydrolysis and cytokine signaling pathways By competitively binding PDE4 s catalytic domain apremilast prevents intracellular cAMP degradation (IC50 0 074 M Ki 68 nM) thereby suppressing production of inflammatory mediators such as tumor necrosis factor- interleukin-23 CXCL9 and CXCL10 Due to these anti-inflammatory effects apremilast serves as a significant research tool in autoimmune conditions notably psoriasis and psoriatic arthritis
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Apexbio Technology LLC Regorafenib 755037-03-7 10mM (in 1mL DMSO)
Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research
Apexbio Technology LLC Lopinavir 192725-17-0 10mM (in 1mL DMSO)
Lopinavir is an inhibitor targeting the human immunodeficiency virus (HIV) protease enzyme implicated in viral polyprotein cleavage and maturation Structurally analogous to ritonavir lopinavir binds to HIV protease and suppresses catalytic activity consequently blocking HIV replication It demonstrates potent inhibitory actions against both wild-type and protease-inhibitor-resistant HIV variants Reported inhibition constants (Ki) for lopinavir range between 1 3 and 3 6 pM with antiviral efficacy represented by an EC50 below 0 06 M against protease mutants such as Val82 variants Due to its low susceptibility to inhibition by human serum proteins lopinavir is frequently utilized in antiviral screening assays drug-resistance research and investigations into HIV enzymology and resistance mechanisms
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 1mL
Dimethyl sulfoxide (Standard) is the analytical standard of Dimethyl sulfoxide This product is intended for research and analytical applications Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds Dimethyl sulfoxide has anti-freezing and bacteriostatic properties[1][2]
Apexbio Technology LLC LB42708 226929-39-1 10mM (in 1mL DMSO)
LB42708 (CAS 226929-39-1) is a selective small-molecule inhibitor of farnesyltransferase (FTase) belonging to a non-peptidic pyrrole-based class It blocks FTase-mediated farnesylation of H-Ras N-Ras and K-Ras4B demonstrated by low nanomolar IC50 values (0 8 nM 1 2 nM and 2 nM respectively) LB42708 shows minimal inhibitory effect on geranylgeranyltransferase I In vitro studies indicate inhibition of Ras-driven signaling pathways decreasing Ras activation and subsequently suppressing VEGF-stimulated endothelial proliferation and migration Researchers use LB42708 in oncology and inflammation studies exemplified by reduced tumor growth in Ras-mutant HCT116 and wild-type Caco-2 xenograft models
Apexbio Technology LLC Alexidine dihydrochloride 1715-30-6 10mM (in 1mL DMSO)
Alexidine dihydrochloride is a selective inhibitor targeting mitochondrial protein tyrosine phosphatase 1 (PTPMT1) exhibiting inhibitory activity with an IC50 value of approximately 1 08 M in vitro By inhibiting PTPMT1 Alexidine dihydrochloride modulates mitochondrial signaling pathways implicated in cellular metabolism Additionally this compound enhances insulin secretion in pancreatic -cells of rat islet models In cancer biology research Alexidine dihydrochloride demonstrates activity against FaDu cells providing a relevant tool for studying mitochondrial phosphatase-mediated mechanisms in oncology and diabetes-related research applications