Dimethyl Sulfoxide
Apexbio Technology LLC Mitoxantrone HCl(Synonyms: Mitoxantrone hydrochloride, Novantrone, DHAD, Mitoxantrone HCl, Mitoxantrone dihydrochloride), 10mM (in 1mL DMSO), CAS: 70476-82-3.
Mitoxantrone HCl (CAS 70476-82-3) is an antineoplastic small molecule inhibitor targeting DNA topoisomerase II (Topo-II) Topo-II enzymes manage DNA topology during replication and transcription facilitating chromosome segregation and relieving torsional stress Mitoxantrone interferes with Topo-II-mediated DNA cleavage and ligation inducing double-strand DNA breaks and chromatin rearrangement thus disrupting DNA synthesis and cell cycle progression It modulates activity of immune cells including T cells B cells and macrophages Research demonstrates mitoxantrone s apoptotic or senescence-inducing effects in normal human cell models Its uses in biomedical research include studies on leukemia multiple sclerosis and pancreatic cancer cell viability
Apexbio Technology LLC Dinaciclib (SCH727965)(Synonyms: SCH-727965, SCH727965, Dinaciclib, MK-7965, MK7965), 10mM (in 1mL DMSO), CAS: 779353-01-4.
Dinaciclib (SCH727965 CAS 779353-01-4) is a small-molecule inhibitor targeting cyclin-dependent kinases (CDKs) specifically CDK1 CDK2 CDK5 and CDK9 It exhibits inhibitory potencies with IC50 values of 3 nM for CDK1 1 nM for CDK2 and CDK5 and 4 nM for CDK9 By suppressing CDK activity dinaciclib interrupts cell cycle progression reduces phosphorylation of retinoblastoma (Rb) protein and triggers apoptosis In addition dinaciclib interacts with the acetyl-lysine binding regions within bromodomains Currently in clinical phases I/II it demonstrates antitumor activity both in vitro and in animal models highlighting its potential applicability in oncology research
Apexbio Technology LLC GSK2126458(Synonyms: Omipalisib, GSK-2126458, GSK 2126458, Omipalisib (GSK2126458)), 10mM (in 1mL DMSO), CAS: 1086062-66-9.
GSK2126458 (CAS 1086062-66-9) is a small molecule inhibitor targeting PI3K and mTOR pivotal regulators in cell growth proliferation and tumor progression GSK2126458 demonstrates potent inhibitory activity against PI3K (Ki 19 pM) In colon cancer cells combined use with DDR1-IN-1 enhances its antiproliferative effects Additionally the compound induces G1 phase arrest in BT474 breast cancer cells and sensitizes nasopharyngeal carcinoma (NPC) cell lines to radiation therapy In vivo studies show that combining GSK2126458 with radiation or with MEK and BRAF inhibitors suppresses tumor growth GSK2126458 also influences cellular autophagy pathways highlighting its utility in oncology-focused biomedical research
Medchemexpress LLC SJ6986, Solution 10 mM * 1 mL in DMSO | CAS No. : 2765625-93-0
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 |
Dimethyl sulfoxide | 67-68-5 | MFCD00002089 |
Medchemexpress LLC Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Erdafitinib | 1346242-81-6 | 446.5 g/mol | 1 ML
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 500 mL
Dimethyl sulfoxide | Purity: ≥99.7% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 500 mL
Medchemexpress LLC Lirafugratin10 Mm 1 Ml In Dmso | HY-147250-1ML IN DMSO
Lirafugratin10 Mm 1 Ml In Dmso